Which over-the-counter drug should be avoided during pregnancy due to potential fetal harm?

The choice to avoid ibuprofen (Motrin) during pregnancy is grounded in its potential risks to fetal development. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can impact fetal cardiovascular function, particularly by causing premature closure of the ductus arteriosus, which could lead to significant complications in a developing fetus. Additionally, the use of ibuprofen in the later trimesters of pregnancy may be associated with increased risks of kidney issues and low amniotic fluid levels.

In contrast, Benadryl (diphenhydramine), Tylenol (acetaminophen), and Claritin (loratadine) are generally considered safer choices during pregnancy. For instance, acetaminophen is often recommended for pain relief as it is deemed to have a better safety profile in pregnancy. Diphenhydramine and loratadine are antihistamines that are commonly used for allergic reactions and are also approved for use during pregnancy, although it is always advised to use them under the guidance of a healthcare provider. This distinction underscores the need for careful consideration when selecting medications during pregnancy.